Characterization and Antioxidant Activity of Mahogany Bark Extract-loaded Chitosan Nanoparticles

Syamsul Falah, Sulistiyani Sulistiyani, Dimas Andrianto

Abstract


Nanoparticles-based drug delivery has been recognized to improve the solubility of poorly water-soluble drugs, prolong the half-life of drug systematic circulation by reducing immunogenicity, and releases drugs at a sustain rate. The present study reports on the characterization of mahogany bark extract-loaded chitosan nanoparticles and their antioxidant activity.  Mahogany bark meal was extracted in boiled water for four hours.  Chitosan-sodium tripolyphosphate (STPP) nanospheres were sonicated with ultrasonicator to obtain chitosan-STTP nanocapsules for 30 and 60 min and then were dried with spray dryer. The chitosan-STPP nanocapsules loaded by mahogany extract were then analysed for surface morphology and physical state by scanning electron microscope (SEM) and X ray diffraction (XRD), respectively. Antioxidant activity of the nanoparticles was evaluated by scavenging the 1,1-diphenyl-2-picrylhydrazyl (DPPH) using free radical method. Based on SEM data, the nanoparticle shapes were viewed to adhere to spherical shape. Spherical chitosan-STTP nanoparticles loaded with mahogany bark extract were obtained in the size range of 480 ~ 2000 nm and 240 ~ 1000 nm for 30 and 60 min of ultrasonication time, respectively. The antioxidant activity of the nanoparticles was lower than that of the native mahogany bark extract. 


Keywords


Mahogany; chitosan; nanoparticles; spray drying; ultrasonication.

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References


Falah, S.; T. Suzuki; T. Katayama. 2008. Chemical Constituents from Swietenia macrophylla Bark and Their Antioxidant Activity. Pakistan J. Biol. Sci. 16: 2007-2012.

Falah, S.; M. Safithri; T. Katayama; T. Suzuki. 2010. Hypoglycemic Effect of Mahogany (Swietenia macrophylla King) Bark extracts in Alloxan-induced Diabetic Rats. Indonesia Wood Research Journal 1:91-96.

Hanani, E.; A. Mun’im; R. Sekarini. 2005. Identification of Antioxidant Compounds in Callyspongia sp. sponge from Kepulauan Seribu (in Indonesian). Ilmu Kefarmasian 3:127-133.

Hejazi, R.; M. Amiji. 2003. Chitosan-based gastrointestinal delivery systems. J Control Rel 89:151–165.

Malsch, N.H. 2005. Biomedical Nanotechnology. New York: Taylor & Francis Group.

Mi, F.L.; S.S. Shyu; S.T. Lee; T.B. Wong. 1999. Kinetic Study of Chitosan-tripolyphosphate Complex Reaction and Acid-resistive Properties of the Chitosan-tripolyphosphate Gel Beads Prepared by in-liquid Curing Method. J Polym Sci 37:1551-1564.

Mohanraj, V.J.; Y. Chen. 2006. Nanoparticles-A Review. Tropical J Pharm Res 5:561-573.

Yen, M.; J. Yang; J. Mau. 2008. Antioxidant properties of chitosan from crab shells. Carbohydrate Polymer 74: 840-844.




DOI: https://doi.org/10.51850/wrj.2012.3.2.94-99

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