Evaluation of Isolated Compounds from Wood of Artocarpus heterophyllus as A Cosmetic Agent

Enos Tangke Arung, Kuniyoshi Shimizu, Ryuichiro Kondo

Abstract


In our efforts to find new whitening agent materials, we focused on wood of Artocarpus heterophyllus which is anti melanogenesis. By activity-guided fractionation of A. heterophyllus wood extract, norartocarpetin and artocarpesin were isolated which inhibited both mushroom tyrosinase activity and melanin formation in B16 melanoma cells. This compound is a strong candidate as a remedy for hyperpigmentation in human skin that can be used for cosmetic (whitening agent).


Keywords


tyrosinase; melanin; hyperpigmentation; wood; Artocarpus heterphyllus.

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References


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DOI: https://doi.org/10.51850/wrj.2010.1.1.40-44

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